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Prokaryotic cytoskeleton
The prokaryotic cytoskeleton is the collective name for all structural filaments in prokaryotes. It was once thought that prokaryotic cells did not possess cytoskeletons, but advances in visualization technology and structure determination led to the discovery of filaments in these cells in the early 1990s. Not only have analogues for all major cytoskeletal proteins in eukaryotes been found in prokaryotes, cytoskeletal proteins with no known eukaryotic homologues have also been discovered. 〔 〕 Cytoskeletal elements play essential roles in cell division, protection, shape determination, and polarity determination in various prokaryotes.〔 〕
==FtsZ==
FtsZ, the first identified prokaryotic cytoskeletal element, forms a filamentous ring structure located in the middle of the cell called the Z-ring that constricts during cell division, similar to the actin-myosin contractile ring in eukaryotes. The Z-ring is a highly dynamic structure that consists of numerous bundles of protofilaments that extend and shrink, although the mechanism behind Z-ring contraction and the number of protofilaments involved are unclear.〔 FtsZ acts as an organizer protein and is required for cell division. It is the first component of the septum during cytokinesis, and it recruits all other known cell division proteins to the division site.
Despite this functional similarity to actin, FtsZ is homologous to eukaryal tubulin. Although comparison of the primary structures of FtsZ and tubulin reveal a weak relationship, their 3-dimensional structures are remarkably similar. Furthermore, like tubulin, monomeric FtsZ is bound to GTP and polymerizes with other FtsZ monomers with the hydrolysis of GTP in a mechanism similar to tubulin dimerization. Since FtsZ is essential for cell division in bacteria, this protein is a target for the design of new antibiotics.
There currently exist several models and mechanisms that regulate Z-ring formation.One of the model of Z-ring formation was proposed by Rashid, Aijaz and Sing, Perminder. Critical Concentration Gradient Model of Bacterial Cell Division. Available from Nature Precedings (2010).According to this model positive and negative regulators of FtsZ assembly form a gradient inside the bacterial cell. The gradient is such that critical concentration of FtsZ required for FtsZ assembly is minimum at medial position of cell,hence Z-ring and ultimately divisome complex is formed at middle of cell.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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